Substances

Psychedelics. Hallucinogens. Entheogens. Empathogens. These are among the many names ascribed to the class of substances which have been shown to expand consciousness, promote greater self-awareness, and hold potential for healing and personal evolution. It is these potentials which inspired the creation of psychedelic societies across the globe. Anyone considering psychedelic use should know that these are powerful substances with life-altering affects and great care should be taken in making this choice. We firmly believe that anyone looking to use psychedelics would best be served by fully understanding the risks and rewards involved. Below is a list of the most common of these substances with links to educational websites which can provide solid information before you take the journey…

PSYCHEDELICS

Indole Alkaloids - All of these molecules contain indole (a benzene ring attached to a pyrrole ring).
Tryptamines - These molecules are similar enough to the neurotransmistter Serotonin (5-hydroxytryptamine) to bind to its receptors.

(Serotonin Partial Agonists)

Tryptamine

Serotonin (5-HT)

N,N-DMT (N,N-Dimethyltryptamine) (Erowid) (Psychonaut Wiki) (Third Wave)

Found in Psychotria viridis (Chacruna), Diplopterys cabrerana (Chaliponga),

Mimosa tenuiflora/hostilis (Jurema), Acacia confusa, Synthetic, Endogenous

Component of Ayahuasca brews (Erowid) (Psychonaut Wiki) (Third Wave)

Psilocybin (4-PO-DMT) (Erowid) (Psychonaut Wiki) (Third Wave)

Prodrug to Psilocin (4-HO-DMT)

Found in nearly 200 mushroom species, notably Psilocybe cubensis and Panaeolus cyanescens

Mushrooms can also include Baeyocystin, Norbaeyocystin, Aeruginascin, Serotonin, Harmalas, and more

Long history of Mesoamerican entheogenic use, especially in Aztec society

Currently used ceremonially by the Mazatec in Oaxaca, where the mushrooms are known as 'Niños Santos'

Psilocybin & psilocin were isolated and identified by Albert Hofmann in the late 1950s

Synthetic psilocybin is currently in Phase 2 clinical trials for depression treatment

4-AcO-DMT (Psilacetin / O-Acetylpsilocin) (Erowid) (Psychonaut Wiki) (Third Wave)

Semi-synthetic research chemical, possible prodrug to Psilocin (4-HO-DMT)

Similar research chemicals include 4-HO-DPT (Procin), 4-HO-MiPT (Mirprocin), and 4-HO-MET (Metocin)

Bufotenin (5-HO-DMT) (Erowid) (Psychonaut Wiki)

Found in Anadenanthera peregrina (Yopo), Anadenanthera colubrina (Cebil), Toad venoms, Endogenous

Yopo and Cebil seeds are used in entheogenic snuffs by various South American tribes

5-MeO-DMT (Erowid) (Psychonaut Wiki) (Third Wave)

Found in Bufo/Incilius alvarius venom, Virola theiodora/elongata resin, Synthetic, Endogenous

β-Carbolines

Harmine & other Harmala Alkaloids (Erowid) (Psychonaut Wiki)

Inhibiters of Monoamine Oxidase (MAO) in addition to psychedelic activity

Found in Banisteriopsis caapi (Ayahuasca/Yage), Peganum harmala (Syrian Rue), Passiflora sp., Tobacco

Ayahuasca vine contains Harmine, Harmaline, and THH (Tetrahydroharmine)

The vine is used ceremonially by various South American tribes, usually in conjunction with a DMT plant

Some beta-carboline MAOIs are endogenous (Harmane, Norharmane, Pinoline)

Terpenoid Indoles

Ibogaine (Erowid) (Psychonaut Wiki) (Third Wave)

Found in Tabernanthe iboga, Voacanga africana, Tabernaemontana undulata (Sananga), Synthetic

Occurs alongside other indoles like Ibogamine, Noribogaine, and Voacangine

Used ceremonially by the Bwiti in central West Africa

Potent addiction breaker with psychedelic and dissociative effects lasting for several days

Interacts with many receptor systems (serotonin, dopamine, NMDA, opioid, acetylcholine)

Ergolines/Lysergamides

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LSD (Lysergic Acid Diethylamide) (Erowid) (Psychonaut Wiki) (Third Wave)

Semi-synthetic, derived from Claviceps purpurea (Ergot), originally by Albert Hofmann in 1938

Strongest psychedelic by weight - active in micrograms. Sticky molecule creates long duration (8-20hrs)

Also binds to dopamine receptors, providing faster, more energetic experience than tryptamines

See also: ALD-52, 1P-LSD, AL-LAD, ETH-LAD

Some tabs claiming to be acid are actually 25i-NBOMe - use reagent test kits to determine what you have

D-lysergic_acid_methyl_carbinolamide.svg.png

LSH (Lysergic Acid Hydroxyethylamide) (Erowid) (Psychonaut Wiki)

Very unstable, quickly degrades into the sedative LSA (Lysergic Acid Amide)

Found in fresh seeds of Ipomoea tricolor (Heavenly Blue Morning Glory/Tlitliltzin),

Rivea/Turbina/Ipomoea corymbosa (Ololiuqui), Argyreia nervosa (Hawaiian Baby Woodrose),

where it is produced by a symbiotic fungus related to ergot.

These seeds were the most sacred entheogen in Aztec culture

Phenethylamines - These molecules are similar to the neurotransmitter Dopamine (3,4-dihydroxyphenethylamine). Most substituted phenethylamines are stimulants, such as the amphetamines, but the ones listed below but still agonize serotonin receptors, creating psychedelic effects.

Phenethylamine

Dopamine

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Mescaline (3,4,5-Trimethoxyphenethylamine) (Erowid) (Psychonaut Wiki) (Third Wave)

Found in endangered Peyote (Lophohora williamsii) with >50 other alkaloids (Erowid) (Third Wave)

And in columnar cacti such as San Pedro (Echinopsis/Trichocereus Pachanoi) (Erowid) (Third Wave),

Bolivian Torch (Echinopsis langeniformis / Trichocereus bridgesii),

and Peruvian Torch (Echinopsis peruviana / Trichocereus peruvianus)

Mescaline cacti have a history of ceremonial use in South & Central America dating as far back as 6000 years

First psychedelic molecule identified by science (in 1897), and thus has the longest history of research

More physical, longer lasting, and much weaker by weight than tryptamines

MDMA (3,4-Methylenedioxymethamphetamine) (Erowid) (Psychonaut Wiki) (Third Wave)

Synthetic entactogen / empathogen amphetamine also known as Ecstasy/E/XTC or Molly

Currently in Phase 3 clinical trials for PTSD treatment

Pills are widely adulterated, so test using reagent test kits

2C-B (4-Bromo-2,5-dimethoxyphenethylamine) (Erowid) (Psychonaut Wiki) (Third Wave)

Synthetic research chemical discovered by Alexander Shulgin, also known as Bromo Mescaline or Nexus

DISSOCIATIVES
Arylcyclohexylamines (NMDA Antagonists)

Ketamine (Erowid) (Psychonaut Wiki) (Third Wave)

Synthetic dissociate anaesthetic used in medicine and administered in clinics for depression treatment

Developed in 1963 to replace the similar arylcyclohexylamine PCP
Produced the nematophagous fungus Pochonia chlamydosporia

Atypical Dissociatives (Kappa Opioid Agonists)

Salvia Divinorum (Erowid) (Psychonaut Wiki) (Third Wave)

Contains the potent diterpenoids Salvinorin A & B

No longer grows in the wild. Federally legal, sold in headshops in many US states

Cultivated by the Mazatec as 'Ska Pastora', who use it orally to connect to the Virgin Mary

PSYCHEDELICS Indole Alkaloids - All of these molecules contain indole (a benzene ring attached to a pyrrole ring). Tryptamines - These molecules are similar enough to the neurotransmistter Serotonin (5-hydroxytryptamine) to bind to its receptors.